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Men with poor liver function may need lower doses of this medication. Daily use of this medication is not recommended. It should not be used more frequently than 3 times per week. Once-a-day use with 5 mg dosing or less may be considered for some patients with liver problems. Nitrate-containing medications: Tadalafil should never be taken with any medications that contain nitrates. Blood pressure may drop to life-threatening levels if tadalafil is taken with any nitrate-containing medication e. Dizziness, fainting spells, heart attack, or stroke may be experienced. If use of a nitrate-containing medication is considered medically necessary, 48 hours must pass after the last dose of tadalafil before taking a nitrate, and only under close medical supervision. Penis deformation: As with other medications for erectile dysfunction, men with an anatomical deformation of the penis such as angulation, cavernosal fibrosis, or Peyronie's disease should be closely monitored by their doctors if they take this medication. If you have any of these conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Prolonged erection priapism : If an erection lasts longer than 4 hours a rare occurrence , seek immediate medical assistance. If this condition is not treated quickly, tissue damage and permanent loss of the ability to have an erection could result. Tell your doctor if you have any of the following conditions, as they may increase your risk of a prolonged erection: sickle cell anemia, multiple myeloma, or leukemia. Prostate problems: If you are taking other medications to treat BPH called alpha blockers e. The combination of alpha blockers with tadalafil is not recommended for treatment of BPH. People who are taking tadalafil for erectile dysfunction may be able to continue taking alpha blockers. Talk to your doctor for more information. Vision problems: If you experience a sudden loss of vision in one or both eyes, or other vision-related problems, contact your doctor immediately. Vision loss may be partial or complete. While in some cases the condition may improve over time, it can be permanent in other cases. This is a rare condition that more likely to occur if you have heart disease, high blood pressure, high cholesterol, diabetes, or eye problems, if you are more than 50 years old, or if you smoke. Children and adolescents: Tadalafil is not intended for use by children or adolescents under 18 years old. If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:. An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed. Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter non-prescription , and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. All material copyright MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www. About this Medication. 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